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Apoptosis in Health and Disease: Clinical and Therapeutic by Martin Holcik, Eric C. LaCasse, Alex E. MacKenzie, Robert G. PDF

By Martin Holcik, Eric C. LaCasse, Alex E. MacKenzie, Robert G. Korneluk

ISBN-10: 0521529565

ISBN-13: 9780521529563

The method of programmed mobile demise or apoptosis has, within the decade previous the e-book of this 2005 ebook, been proven to be centrally considering the pathogenesis of the numerous majority of human health problems and damage states. The mobile attrition saw in such a lot degenerative stipulations is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many varieties of melanoma. The crucial position of apoptosis in human illness basically brings with it scientific promise; for instance, the robust threat exists that attenuation of apoptotic dying will considerably modulate the severity of degenerative issues. equally, stipulations, resembling melanoma, autoimmune ailment, psoriasis and endometriosis, during which aberrant mobile proliferation is saw, could benefit from better premiums of apoptosis. This booklet surveys the underlying molecular mechanisms of apoptosis, investigates its position in degenerative and different ailments, and evaluates strength treatments that would let acceptable activation or inhibition of apoptosis in illness and damage states.

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Extra resources for Apoptosis in Health and Disease: Clinical and Therapeutic Aspects

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The CARD domain: a new apoptotic signalling motif. Trends Biochem. , 22, 155–6. , Thompson, C. , Lefebvre, C. , MacKenzie, A. , and Korneluk, R. G. (2000). The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)deleted mice display increased vulnerability to kainic acid-induced injury. Proc. Natl. Acad. Sci. USA, 97, 2286–90. Hornsby, P. J. and Didenko, V. V. (2002). In situ DNA ligation as a method for labeling apoptotic cells in tissue sections. An overview. Methods Mol. , 203, 133–41.

Com 4 Immunex (Amgen) ? ) 22 E. C. LaCasse et al. ) Company or institution (partner, collaborator, Class (∗ ) acquisition, or parent) Drug(s)/therapeutic(s) Description of agent or strategic approach References or website address 4 Regeneron (Novartis) IL-1 TRAP IL-1 antagonist 4 Sankyo TRA-8 DR5 MoAb 4 Schering-Plough PEG-Intron 4 Xencor DN-TNF 5 5 Aegera Ariad ? Argent/AP-1903 5 Calydon CV706 5 5 Entremed GeminX ICP10 PK (HSV2) E4orf4 5 GenVec TNFerade 5 5 GTI (Novartis) Introgen (Canji) OAV001, OAS403 RPR/INGN201 5 ?

Histochem. , 38, 275–339. , Robertson, J. , and Orrenius, S. (2002). Cytochrome c release from mitochondria proceeds by a two-step process. Proc. Natl. Acad. Sci. USA, 99, 1259–63. , Reed, J. C, and Godzik, A. (2001). PAAD – a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem. , 26, 85–7. Pecora, A. , Cohen, G. I. et al. (2002). Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers. J. Clin. , 20, 2251–66.

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Apoptosis in Health and Disease: Clinical and Therapeutic Aspects by Martin Holcik, Eric C. LaCasse, Alex E. MacKenzie, Robert G. Korneluk


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